With eight years of experience at the ICMR-Antimicrobial Surveillance Network, I specialize in applying AI/ML in healthcare (specifically to enhance infectious disease surveillance). My contributions have led to over 20 publications, including significant findings on AMR recently published in The Lancet Regional Health Southeast Asia.
AMRSense is a One Health Data Ecosystem for solving the challenge of Antimicrobial Resistance. Brought to reality by a collaboration between IIIT-Delhi, ICMR, CHRI-PATH, and Tata 1mg.com, AMRSense closes the gaps in data and AI for evidence-based implementation of AMR surveillance.
Jasmine Kaur, Nittin Yadav, Tavpritesh Sethi, Harpreet Singh (ICMR), Tikesh Bisen (CHRI/PATH), Nikhil Doegar (TATA 1mg)
Revolutionizing Resource Management in Primary Health Centers with Digital Process Optimization
Jasmine Kaur, Aditya Kumar, Pradeep Singh, Tavpritesh Sethi
Background: Antimicrobial resistance (AMR) has escalated to pandemic levels, posing a significant global health threat. This study examines the patterns and trends of AMR in Bloodstream Infections (BSIs) across India, aiming to inform better surveillance and intervention strategies. Methods: Six-year data from 21 tertiary care centers in the Indian Council of Medical Research's AMR Surveillance Network (IAMRSN) were retrospectively analyzed to estimate cluster-robust trends in resistance. Time-series analysis was used to discern lead/lag relationships between antibiotic pairs and the directional influence of resistance in community and hospital-acquired BSIs(CA/HA BSIs). A data-driven Bayesian network ensemble averaged over 301 bootstrap samples was modelled to uncover systemic associations between AMR and Sustainable Development Goals (SDGs).Findings: Our findings indicate significant (p < 0.001) monthly increases in Imipenem and Meropenem resistance for Klebsiella, E. coli, and Acinetobacter BSIs. Importantly, Carbapenem resistance in HA-BSIs preceded that in CA-BSIs for Klebsiella and Acinetobacter (p < 0.05). At a national level, Cefotaxime resistance emerged as a potential early indicator for emerging Carbapenem resistance, proposing a novel surveillance marker. In Klebsiella BSIs, states with higher achievement of SDG3 goals showed lower Imipenem resistance. A model-based AMR scorecard is introduced for focused interventions and continuous monitoring.Interpretation: The identified spatiotemporal trends and drug resistance associations offer critical insights for AMR surveillance aligning with WHO GLASS standards.The escalation of carbapenem resistance in BSIs demands vigilant monitoring and may be crucial for achieving SDGs by 2030. Implementing the proposed framework for data-driven evidence can help nations achieve proactive AMR surveillance.
Read moreJasmine Kaur, Harpreet Singh, Tavpritesh Sethi
Urinary Tract Infections (UTIs) affect nearly 150 million people worldwide annually. High antimicrobial resistance (AMR) is reported in India. However, no studies provide multicentric, nationwide data on trends and associations of AMR in UTIs. To our knowledge, this study presents the most comprehensive estimates of trends and associations of AMR across India.
Read moreJasmine Kaur, Aditya Nagori, Balaji Veeraraghavan, Vinod Ohri, Rakesh Lodha, Kamini Walia, Harpreet Singh, Tavpritesh Sethi